Antenatal magnesium sulphate may prevent cerebral palsy in preterm infants—but are we convinced? Evaluation of an apparently conclusive meta-analysis with trial sequential analysis

External Link: Antenatal magnesium sulphate may prevent cerebral palsy in preterm infants—but are we convinced? Evaluation of an apparently conclusive meta-analysis with trial sequential analysis

URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1471-0528.2010.02782.x/ full

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Resource Information

  • Description: Cerebral palsy is a condition with chronic, nonprogressive disability of the central nervous system, which has major personal and socioeconomic burdens. For preterm infants, the risk of cerebral palsy increases inversely with gestational age at birth. Several studies have indicated that magnesium sulphate given to women at risk of preterm birth may be neuroprotective for the fetus. Meta-analyses of the data from randomised clinical trials (RCTs), comparing magnesium sulphate against placebo for women at risk of preterm birth, have revealed a significant preventive effect on cerebral palsy in the child without observed serious adverse drug effects. The meta-analyses found no overall difference in mortality (fetal and later deaths) between the magnesium sulphate and placebo groups.
  • Type: Report : None

    • Relationships

  • Member of:
  • Collection : ChiMat Research
  • Collection : Maternity: Research

  • Author


  • LD Huusom, Department of Gynecology and Obstetrics, Hvidovre Hospital

    • Publishing

  • Published by: BJOG: An International Journal of Obstetrics & Gynaecology
  • Published date: Friday, 10th December 2010 00:00:00

    • Subject

  • Keywords (National Public Health Language):
  • AGE
  • AGE GROUPS
  • ANALYSIS
  • ASSESSMENT
  • BABIES
  • BIRTH
  • CENTRAL NERVOUS SYSTEM
  • CEREBRAL PALSY
  • CHILD
  • CHILDBIRTH
  • CHILDREN
  • CLINICAL TRIALS
  • CNS
  • DATA
  • DEATH
  • DEATH, DISEASE AND DISABILITY
  • DRUGS
  • EVALUATION
  • EVALUATION REPORT
  • GROUPS
  • INFANTS
  • INFORMATION
  • MEASURES, METHODS, RESEARCH, THEORIES
  • MEDICINES
  • MORTALITY
  • NEUROLOGICAL DISEASES AND DISORDERS
  • ORGAN SYSTEMS
  • PEOPLE AND POPULATIONS
  • PHYSICAL DEVELOPMENT
  • PLACEBOS
  • RANDOMISED CONTROLLED TRIALS
  • RCTS
  • RESEARCH
  • RESEARCH METHODS
  • WOMEN
  • Category (Government Category List):
  • MEDICINES
  • RESEARCH
  • WOMEN

    • Other

  • Source: BJOG: An International Journal of Obstetrics & Gynaecology Volume 118, Issue 1, pages 1–5, January 2011

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    • URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1471-0528.2010.02782.x/ full

    Click here to view

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